In vitro acid triggered drug release studyThe oxime bond formed


Compared with the traditional structure of nanocarrier33,34, our designed PEG DOX Cur NPs possessed higher drug loading capacity, as the drugs directly acted as the hydrophobic core. The result suggested that the prodrug nanoparticle can co deliver multiple therapeutic agents with a single nanocarrier.Figure 2The synthetic route to PEG DOX (A) and 1H NMR spectra of mPEG CHO (B) and PEG DOX (C).In vitro acid triggered drug release studyThe oxime bond formed by Schiff’s base between PEG and DOX could specifically be hydrolyzed under acid environments35,36, which would result in the disassembly of nanoparticles and the acceleration of the drug release. As depicted in Fig.

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